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In sepsis, excessive neutrophil activation and NET release shift the endothelium from an anti-inflammatory and anticoagulant phenotype to a pro-inflammatory and pro-coagulant phenotype

Huang XY, Chao DY, Koprivova A, Danku J, Wirtz M, Muller S, Sandoval FJ, Bauwe H, Roje S, Dilkes B, et al

Seventeen patients were enrolled, and eleven patients completed the study

Following incubation and washing, TMB substrate solution is then used to visualize the HRP enzymatic reaction by catalysis to produce a blue-coloured product that changes to yellow after addition of acidic stop solution

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Lithium improved depressive and cognitive deficits, reduced GSK-3 expression and tau hyperphosphorylation, prevented neuroinflammation, and increased neuronal survival