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STORAGE To be stored at room temperature away from direct sunlight

Start and stop times work too, but a clear total time statement is the simplest approach

The predominant side effects include: Gastrointestinal symptoms : nausea, vomiting, diarrhoea, constipation, and abdominal pain (affecting 10-50% of patients depending on the specific product and dose, particularly during dose escalation) Injection site reactions : redness, itching, or discomfort at the subcutaneous injection site Hypoglycaemia : particularly when combined with insulin or sulphonylureas Decreased appetite : an intended therapeutic effect that contributes to weight loss However, some patients do report changes in urinary frequency or patterns

Some clinicians use oral as a maintenance route after an initial subcutaneous course, but this is pragmatic, not evidence-defined

Before modern treatments for lupus, less than 50 percent of people lived for five years after receiving their diagnosis

doi:10.1053/j.ackd.2018.02.010