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(PubMed) How TB-500 Works TB-500 is not full-length TB4 its the N-acetylated 1723 fragment (Ac-LKKTETQ) that corresponds to TB4s actin-binding region

However, this strategy is only attractive if the therapeutic agent itself is not a substrate for CPA, or if the case, that its functional activity is not negatively affected by C-terminal cleavage

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Elucidation of the GSK3alpha Structure Informs the Design of Novel, Paralog-Selective Inhibitors

Safety, tolerability, pharmacokinetics, and clinical outcomes following treatment of painful knee osteoarthritis with senolytic molecule UBX0101

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