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Iron imunomodulates the termination of the inflammatory response, as elevated Fe level increase the M2 phenotype and reduce the pro-inflammatory M1 response, reducing the IL-12/IL-10 balance

that had not previously been as impacted by the drug

10.1038/s43247-025-02169-5 193 HsiaoC

Biochemically, GGT is associated directly with GSH regulation and maintenance of its normal redox status in cells by breaking down extracellular GSH which cannot cross the cellular membrane to release cysteine and glycine building blocks which can more easily cross into the cell for de-novo synthesis of GSH during periods of oxidative stress [26]

Therefore, applying tomato paste may offer similar protection against both immediate and long-term UV-induced skin damage

Aldrich SM, Regal RE