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Available from: National Institutes of Health (NIH) Office of Dietary Supplements

Possible NAD+ injection side effects tend to be mild and short lived as your body adjusts, and may include: Injection site discomfort Brief flushing Headache Mild nausea Temporary fatigue Report anything persistent or severe to your provider, who monitors your response throughout treatment

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Tears and degenerative changes within the substance of the tendon would be an absolute contraindication to Achilles tendon injection

and REDEFINE 11, a phase 3 trial with longer duration and other protocol changes compared to REDEFINE 1 and 2