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Hypercobalaminemia has been observed in both solid and hematological malignancies at diagnosis [129] and is associated with an increased risk of prostate cancer [130] (Figure 2B)

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This is primarily through the reduction in the number of commensal microbes essential in maintaining intestinal homeostasis, particularly those that produce SCFAs such as butyrate, which acts as a nutrient source for enterocytes (Louis et al

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