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64, 65 Some findings strongly indicate that ROS in the rostral ventrolateral medulla is increased in stroke-prone spontaneously hypertensive rats and thereby contributes to the neural mechanisms of hypertension through activation of the sympathetic nervous system

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10.1152/ajprenal.00221.2019 Am J Physiol Renal Physiol

The aim is not to replace Bayesian MIPD, but to extend it toward more adaptive, trajectory-based pharmacokinetic reasoning by integrating temporally dense clinical data, evolving physiological states, and clinician-guided interpretation