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92 It also promotes expression of aggrecanases ADAMTS-4 and ADAMTS-5, with histological assessments confirming proteoglycan loss following LEP treatment

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Kudo, S., Mizuta, H., Otsuka, Y., Takagi, K

In November 2012, cabozantinib, a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, was approved for thyroid cancer [56] and also in April 2016 was accepted as second-line treatment for RCC [57]

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Leckstrom, A., Bjorklund, K., Permert, J., Larsson, R