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Meanwhile, the PD group had the highest levels, followed by the progressive supranuclear palsy (PSP) group and then the MSA group, compared with the control group (Yamagishi et al., 2018)

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The study showed that the NOAEL of rotigotine behenate-loaded PLGA was at 360 mg/kg, supporting its safety and potential for clinical translation 138

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[DOI] [PMC free article] [PubMed] [Google Scholar] 115.Tait J.L., Duckham R.L., Rantalainen T., Milte C.M., Main L.C., Nowson C.A., Sanders K.M., Taaffe D.R., Hill K.D., Abbott G., et al