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Measuring MMA levels improves diagnostic sensitivity and specificity for cobalamin deficiency not only because Hcy elevation can occur in various conditions, but also because approximately 50% of cobalamin-deficient patients may have normal serum cobalamin levels leading to under-diagnosis (Romagnolo et al

The small link in some studies may come from other factors

These statements also apply to B12 therapy with the use of oral supplements

[] Another study demonstrated that in a transverse aortic constriction murine model of HF, reduced PGC-1 mRNA expression is correlated with significant attenuation of H3K9ac levels

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CD38 Exacerbates Focal Cytokine Production, Postischemic Inflammation and Brain Injury After Focal Cerebral Ischemia