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Description

Severe allergic reactions, persistent edema, or signs of high IGF-1 (joint pain, carpal tunnel, headaches) warrant clinical review

However, only 2 of the 11 studies were conducted in human subjects (Balaji et al., 2021)

Start (Weeks 12): 20 mcg once daily to assess tolerance, particularly any effect on blood glucose

Retatrutide itself remains an investigational compound it has not received marketing authorisation from the MHRA in the UK, the European Medicines Agency (EMA), or the US Food and Drug Administration (FDA)