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10.1016/j.celrep.2018.09.038 20 GotohK.InoueM.MasakiT.ChibaS.ShimasakiT.AndoH.et al (2012)

Polymorphisms in TNFAIP3 and elevated levels of circulating proteasomes are also associated with RA, further implicating the UPS in disease pathogenesis

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For researchers combining exercise with performance peptides , understanding this mechanism helps explain why exercise amplifies the cognitive benefits of compounds like Semax and Selank