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Mast cells express IgE receptor (FcRI), release histamine and play important role in mediating various allergic reactions (Frieri et al., 2017b)

Your digestive tract's lining can thin out when collagen breaks down, which might cause stomach problems [3]

The following are known triggers of mast cell degranulation (in addition to IgG activation via pathogen or allergen):[ref] Acetylcholine Complement fragments (C3, C4, C5) Various drugs, environmental toxins (MRGPRX2 receptor, details below) Peptides (including endorphin, leptin, PTH, and more) Physical conditions (cold, heat, pressure, stress, and vibration)