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To restore vitamin B12 levels and also fight vitamin b12 deficiency, administer half of the above doses and repeat at 12-week intervals, if necessary

Under hypoxic conditions, L-2-hydroxyglutarate (L-2-HG) was proven to be generated by lactate dehydrogenase A (LDHA) and malate dehydrogenase (MDH) 88,89

GPx4 is a membrane-bound enzyme and the only enzyme that directly reduces lipid hydroperoxides and large lipid molecules such as cholesterol and phospholipids

What's remarkable about all eight conditions is that pharmacologic intervention alone is not the answer and neither, for many, is behavior change

Summary: B12 deficiency may be caused by malabsorption, poor dietary intake and/or pernicious anemia

In the vessel wall, impairment of lipid metabolism could cause pathologic lipids accumulation ( The oxidative imbalance may be inevitably enhanced during the atherosclerotic plaque progression as long as the modified lipoproteins and reinforcements possess proinflammatory properties (Figure 1)