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Pathogenic and non-pathogenic variants are proposed to exist

In addition to DNA synthesis, B12 is vital for energy production, as it acts as a cofactor for certain enzymes involved in cellular energy metabolism in the mitochondria

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Copper is involved in melanin synthesis (hair pigmentation) and is a cofactor for enzymes involved in keratin cross-linking

[42] The amplification of the cell surface receptor MET often drives resistance to anti-EGFR therapies in colorectal cancer

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