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Thus, xCT inhibitors enhance mitochondrial respiration and increase ROS production to promote ferroptosis, which may be a potential therapeutic strategy in cancer cells exhibiting metabolic reprogramming from glycolysis to OXPHOS

For instance, patients aiming for weight management might require different dosing compared to those focusing on glycemic control

Therefore, in some ways, it reflects that ferroptosis plays an important role in the progression of DKD

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doi: 10.21037/pcm-21-9 182 VozeninM-CDe FornelPPeterssonKFavaudonVJaccardMGermondJ-Fet al