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Clinically approved agents such as dimethyl fumarate exemplify this therapeutic potential, demonstrating dual metabolic effects in cerebral ECs: enhanced glycolytic flux via phosphoglycerate dehydrogenase inhibition, and suppressed mitochondrial respiration through serine/glycine synthesis downregulation (Ocaa et al., 2023)

However, avoid excessive doses potentially interfering with necessary acute inflammation

EspositoLCancroFPSilverioAdi MaioMIannecePDamatoAet al

Factors Affecting Dosing Frequency Long Half-Life: It appears to have a prolonged biological activity, potentially lasting days after administration

Intestinal barrier dysfunction and microbiotagutbrain axis: Possible implications in the pathogenesis and treatment of autism spectrum disorder

Paul Jones, MD10