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Exogenous risk factors such as an exposure to ultraviolet light, increase melanoma incidence, as well as skin damage with burns, frostbite and damage after radiotherapy, although the mechanism of the latter is not always clear

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Chem (2001)

MMP Regulation: Balancing Breakdown and Repair Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for degrading extracellular matrix components

It didn't hurt though so think I will be able to work up the courage to eventually inject myself in my thigh

The irritation is relatively typical but something to be aware of