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Its endogenous form has a plasma half-life of only 2-3 minutes due to rapid degradation by dipeptidyl peptidase-4 (DPP-4) and renal clearance

11 The anatomical linchpin is the area postrema, a small hindbrain structure that sits outside the bloodbrain barrier and is therefore directly exposed to circulating hormones

Research for effective treatments for Alzheimers disease (AD) is ongoing, but drug development faces challenges with a high failure rate

Despite initial pharmaceutical interest, AOD 9604 did not progress through the full clinical trial pathway required for regulatory approval, and it holds no Marketing Authorisation (MA) from the MHRA or EMA

According to NICE Clinical Knowledge Summaries and the British National Formulary , the standard treatment is intramuscular injections of 1,000 mcg (1 mg) hydroxocobalamin