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Authors : Parameswaran G Sreekumar, Keijiro Ishikawa, Chris Spee, Hemal H Mehta, Junxiang Wan, Kelvin Yen, Pinchas Cohen, Ram Kannan, David R Hinton Source : The study investigates the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effects on oxidative stressinduced cell death, mitochondrial bioenergetics, and senescence

Bhattasali O, Holliday E, Kies MS, Hanna E, Garden AS, Rosenthal DI , Morrison WH, Gunn GB, Fuller CD, Zhu XR, Frank SJ

Hypothalamic inflammation as a potential pathophysiologic basis for the heterogeneity of clinical, hormonal, and metabolic presentation in PCOS

Patients should seek immediate medical attention for severe, persistent abdominal pain (which could indicate pancreatitis), symptoms of gallbladder disease (right upper quadrant pain, fever, jaundice), or inability to keep any fluids down for 24 hours

Staying at each dose level for 6 weeks instead of 4 reduces side effects for sensitive individuals

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