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A B12 deficiency can also be responsible for depressive episodes, anxiety disorders and mood swings and can lead to inflammation and ulcers throughout the digestive tract starting in the mouth with aphthae and inflammation of the tongue (so-called Hunters glossitis)

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Studies have shown that improving skin barrier function during the application of retinoids could reduce the risk of skin irritations

(2022)reported that treating a PCOS-IR rat model established by letrozole combined with a high-fat diet with Modified CFD can regulate the NF-B/LCN-2 inflammatory signaling pathway, thereby inhibiting the release of inflammatory factors and upregulating insulin signal-related genes, and ultimately improving the insulin sensitivity of PCOS-IR rats

Through the disruption of these vital reproductive processes, dysregulation or aberrant exosome activity can lead to infertility (Liu et al., 2024b)

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