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Description

Cap-dependent translation In most eukaryotic mRNAs, translation relies on eukaryotic translation initiation factor 4E (eIF4E) binding to the 5 mRNA cap (a modified nucleotide), along with the ribosome and other initiation factors

This effect was observed by Yang et al

Review on the role of mitochondrial dysfunction in septic encephalopathy

Liu G, Xia P, Li B, Qiao T, Wu Q, Sarfraz MH, Sun Y, Ouyang H, He Y

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

314 Additionally, IDO1 inhibitors, such as epacadostat, target metabolic immunosuppression by blocking the conversion of tryptophan to kynurenine, a pathway that suppresses effector T cell activity while promoting regulatory T cell expansion