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doi:10.2165/00126839-200809010-00002

Natural compounds evaluated in these models have demonstrated promising results across key pathological pathways, including, reduction of oxidative stress, inhibition of AChE, modulation of inflammatory pathways, preservation of blood-brain barrier integrity, enhancement of spatial and memory-related behaviors

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AA-NAT activation is triggered by the activation of 1 and 1b adrenergic receptors by NE (9)

Larger proteins generally excluded though transcytosis possible for specific molecules