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REDEFINE 3 cardiovascular outcomes trial is ongoing (~7,000 participants)

Tadayasu et al., 2025)

It depends on the tissue

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This release of histamine and tryptase increases blood flow to the skeletal muscles during exercise.[ref] Hypoxia has also been shown to induce mast cell degranulation.[ref] This is a normal response for most people, and the body can handle a certain increase in histamine and tryptase