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6 Discussion and future directions This review has summarized how exercise-induced stress responses progress from primary mechanical and organelle signals to secondary metabolic regulation and ultimately to systemic integration across endocrine, immune, and neural networks

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Although the cure rate of depression treatment has improved during the past 40 years, the prevalence rate has not declined (Ormel et al., 2019)

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Accordingly, we made a series of peptides with Phe residues at one or both positions (Table 2)