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In: Shoupe D, editor

10.1016/j.trsl.2021.05.006 80 LuW.LiX.WangZ.ZhaoC.LiQ.ZhangL.et al (2024)

10.1182/blood-2007-07-099465 139 SiesH

This coupling ensures that when methylation demand is high (and SAM levels rise), excess homocysteine is diverted into the transsulfuration pathway to form cysteine, thus preventing the toxic accumulation of homocysteine while supporting glutathione synthesis