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doi:10.3390/ijms23031786 8

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The role of leptin in human obesity and disease: a review of current evidence

CrossRef Network pharmacology and experimental approaches to elucidate the mechanism of Niruryadi Gulika in protecting pancreatic -cells in Type 2 diabetes Rajappan Chandra Satish Kumar, Chittaranjan Das, Dhayalan Kalavathy GokulRaj, Murali Krishna Prasad, Mothishwaran Bhuvaneshwaran, Kunka Mohanram Ramkumar In Silico Research in Biomedicine.2026

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Subsequent studies reveal that RIPK1 and RIPK3 (receptor interacting serine/threonine kinase 3) are key upstream kinases that initiate necroptosis through the phosphorylation of executor protein MLKL (mixed lineage kinase domain like pseudokinase) by multiple regulators [112]