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The remodeling phase, the final and prolonged stage, involves structural refinement of regenerated tissue

Cancer Cell 20 , 576590 (2011)

In this review article, we aimed to update the understanding of the possible roles of HDACs in the pathophysiology of epilepsy, discuss the likely regulatory mechanisms of these enzymes and summarize the recent progress in the development of HDACi in epilepsy rodent models and patients

Definition of the hollow, as a more defined hollow is more amenable to fillers

A single treatment can offer a temporary boost, but sustained benefits require repeated dosing that keeps plasma concentrations elevated over time

This MnCu axis highlights a general principle for metal ion interactions: the phenotypic outcomes are often dictated less by the total metal content than by metal speciation, subcellular redox control, and the capacity of cellular ligands to sequester and detoxify reactive metal pools