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Mitochondrial dysfunction in Kupffer cells plays a central role: IR causes Kupffer cell mitochondria to release mtDNA and ROS, activating NLRP3 inflammasomes which then release IL-1 that amplifies neutrophil recruitment (67)

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs (in Eng)

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Blocking and permeabilization were performed for 1 h at room temperature in PBS containing 2% BSA and 0.1%, 0.2%, 0.5% or 1% Triton X-100 depending on the antigen (Supplementary Data 5)

All samples were acquired on BD LSRFortessa (BD Biosciences)