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For instance, ER and lysosomes interact through the mitochondria-associated endoplasmic reticulum membrane (MAM), mediating calcium ion transport and lipid remodeling, thereby regulating ferroptosis (Annunziata et al

Translational concordance is strong: zebrafish SLC52A3 knock-down and SLC52A3 / mice recapitulate hearing loss, ataxia and early death, all of which improve with systemic riboflavin supplementation (17, 18)

He was able to give resistance with flexion and extension at the knees, and there was slight bilateral ankle dorsiflexion noted

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10.1016/j.chembiol.2020.03.014 5 BersukerK.HendricksJ

Wren, J.N