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In mice with myocardial hypertrophy induced by angiotensin II (ANGII), the expression of SLC7A11 decreased, and the inhibitory effect of SLC7A11 increased the contents of PTGS2, MDA and ROS, which aggravated cardiomyocyte hypertrophy

Hydrogen peroxide affects ion channels in lily pollen grain protoplasts

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The relative concentration of each individual regulator, their individual affinities derived from PL motif recognition and secondary recognition by VPS35, and additional low affinity binding to features of the local environment such as lipids, membrane geometry, F-actin and non-Retromer-interacting proteins, will provide the avidity that defines their enrichment and residency at the Retromer-demarcated retrieval sub-domain

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HEK293 cells expressing Chac1-Myc were treated with MG132, lysosomal acidification inhibitors (Bafilomycin A1 (Baf) or Concanamycin A (CMA)), or the calpain I inhibitor N -Acetyl-L-leucyl-L-leucyl-L-norleucinal (ALLN)