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To block glutathione synthesis pharmacologically we next used buthionine sulfoximine (BSO), a potent inhibitor of GCLC

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J Cancer Res Clin Oncol 149:22592270 Sun J, Bok RA, DeLos Santos R, Upadhyay D, DeLos SR, Agarwal S et al (2021) Resistance to androgen deprivation leads to altered metabolism in human and murine prostate cancer cell and tumor models