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Conclusion In this work, we proposed a combination therapy for AGA by the combination of a flavonoid (Qu) and two metal ions (Zn 2+ and Cu 2+ ), which are sustained delivered using a designed ZCQ/MN nano-composite microneedle patch

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Firstly, children with IUGR show an impaired GH/IGF-I axis, which might be contributing to reduced insulin sensitivity and IGF-I resistance, as higher basal and GH-induced IGF-I levels are required to achieve a growth velocity similar to that of other children, what secondarily leads to a compensatory hyperinsulinemia to counteract insulin antagonistic effects of GH[195] and, an impaired regulation of glucose transporter-4 expression by insulin in muscle and adipose tissue[196]

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