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In tissue-repair research, cell migration matters because the cells that perform repair (fibroblasts, endothelial cells, immune cells) need to physically arrive at the site to do their work

This approach emerged pragmatically from research schedules but aligns well with receptor recovery kinetics and avoids the potential tolerance development that continuous daily dosing over many weeks might produce

Tayran H, Yilmaz E, Bhattarai P et al (2024b) ABCA7-dependent induction of neuropeptide Y is required for synaptic resilience in Alzheimers disease through BDNF/NGFR signaling

At lower doses where waste is significant, the cost advantage narrows

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Duration depends on injury severity and chronicity