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In glioblastoma (GBM), AMPK-HIF-1 signaling reinforces glucose-derived de novo serine synthesis to facilitate tumor growth (100)

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

Rescue experiments using the Wnt agonist BML-284 reverted the phenotypic change in both EMT markers, restoring the cancer phenotype and confirming the signalling pathway-specific mechanism of caudatin action (Figure 2)

Recent data suggests that estragole does not directly cause cancer

References Jensen, M

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