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Importantly, lupus T cells exhibit mitochondrial dysfunction, which is characterized by elevated mitochondrial transmembrane potential ( m ) or persistent mitochondrial hyperpolarization (MHP) that mediates diminished activation-induced apoptosis and predisposes T cells to pro-inflammatory death via necrosis (Gergely et al

Crosstalk: keratinocytes and immune cells in psoriasis

doi: 10.1016/j.coviro.2019.03.004 6 DarcisGKulaABouchatSFujinagaKCorazzaFAit-AmmarAet al

doi:10.1126/science.1166304 69

This process also involves the integration of the undissociated acid within the lipid bilayer under conditions of low external pH, ultimately resulting in the accumulation of anions