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Drug development has a well-documented failure rate: roughly 90% of compounds that show promise in animal models fail in human trials

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BPC-157's triple-proline core disrupts this requirement, explaining in part its documented stability in the presence of gastric acid, trypsin, and pepsin in experimental settings

However, in the only randomized, placebo-controlled pilot study to date examining fecal microbiota transplantation in 11 patients with ME/CFSwhere 5 patients received transplants from a universal donor and 6 underwent autologous fecal microbiota transplantation through colonoscopythere were no notable differences in health-related quality of life metrics between the treatment and placebo groups at both 1- and 6-months post-treatment [163]