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420 Phase III clinical trials have substantiated the non-inferiority of dotinurad in comparison to both febuxostat and benzbromaron

Kotla S, Lee J, Ko KA, Chen W, Samanthapudi VSK, Hoang O, Mejia GF, Li S, Lee H, Zhang A, Cho MS, Schadler KL, Rivera LA, Imanishi M, Tavares Samperio KC, Kim JH, Ostos-Mendoza KC, Mariscal-Reyes KN, Deswal A, Cooke JP, Fujiwara K, Palaskas NL, Koutroumpakis E, Gi YJ, Pathania R, Morrell C, Lorenzi PL, Tan L, Mahmud I, Hanssen NMJ, Afshar-Kharghan V, Hamilton DJ, Yvan-Charvet L, Chini EN, Herrmann J, Vasquez HG, Shen YH, Martin JF, Xu H, Seeley EH, Burks JK, Brookes PS, Wang G, Le NT, Abe JI Circulation research

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USA 81 , 47324735 (1984)

If concomitant ibuprofen use cannot be avoided, monitor patients more frequently for Pemetrexed Injection adverse reactions, including myelosuppression, renal, and gastrointestinal toxicity [see Dosage and Administration (2.5), Drug Interactions (7), and Clinical Pharmacology (12.3)]