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Methyl Group Metabolism in Differentiation, Aging, and Cancer CBS Mutation and Low Sulfur Diet Cystathionine Synthase in Physiology and Cancer PMC The CBS (cystathionine beta synthase) gene catalyses the first step of the transsulfuration pathway, playing a significant role in converting sulfur to sulfate. Mutations in this enzyme may cause excess sulfur in the A proactive genotype to patient phenotype map for cystathionine beta synthase Genome Medicine Springer Nature Link Low homocysteine levels in people with MTHFR Gene mutations.[look for a CBS mutation] Identification of the Cystathionine Beta Synthase [CBS] mutations is important in the diagnosis and management of homocysteinemia. Most of

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