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Patients should speak with their treating clinician about the current evidence, regulatory status, possible alternatives, and whether a treatment plan is appropriate for their medical history

Many research planning windows are shorter 12 to 24 weeks is common for tolerability and titration assessment, with longer cycles for efficacy endpoints

In IMR-5/75, the highest Loewe score is 43.2 and obtained at ~400 nM MitoQ combined with ~500 nM DPI ( Figure 2A )

Reporting followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) where applicable, with emphasis on transparent identification of available evidence rather than quantitative pooling