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Another study by Wan et al., conducted on healthy volunteers, revealed that AUC (0168 h) and AUC (0-) values of gefitinib were higher by 33% and 37%, respectively, in individuals with CA + AA genotypes than in patients with the CC genotype ( p G) of FOXO3 and found a significant association with hepatotoxicity, where the AA carriers had a higher tendency to develop hepatotoxicity than those with GG genotype ( p = 0.018) [96]