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This checkpoint modulation creates permissive conditions for T cell-mediated tumor elimination and provides strong rationale for combining SFN with immune checkpoint inhibitors to overcome therapeutic resistance

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Disclosures: Giuseppe Cullaro: Ocelot Bio: Consultant, Retro Sciences: Consultant, Kavish Patidar: Nothing to Disclose, Andrew Allegretti: Nothing to Disclose, Elizabeth Verna: Salix: Grant/Research Support, Jennifer Lai: Nestle Nutrition Institute: Grant/Research Support, Novo Nordisk: Consultant, Genfit: Consultant, Boehringer Ingelheim: Advisor 939 SOCIAL DETERMINANTS OF HEALTH AND METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE IN CHILDREN WITH OVERWEIGHT OR OBESITY Ananya Venkatesh 1 Nhat Thai 1 Patricia Ugalde Nicalo 1 Kimberly Newton 1 Cynthia Behling 2 Romeo Ignacio 1 Laura Bauman 1 Martha Smith 1 Jeffrey Schwimmer 1 , 1 University of California, San Diego, 2 Pacific Rim Pathology Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common pediatric liver disease

In fact, reduced levels of miR-382 in cells led to an increased expression of CTTN, Rac1 and ARPC2, all players of actin cytoskeleton remodeling

While ASCO recommends the use of duloxetine as a potential treatment for CIPN, sufficient evidence is still lacking

Chen C, Zhao S, Karnad A, Freeman JW