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As Anpep also prevents cellular toxicity from Cys-Gly dipeptide accumulation in addition to promoting cysteine and glycine recovery, we next measured urinary Anpep levels using LC-MS in MRM mode (Figure 3C, peptide determination results are shown in Supplementary Tables S9)

PLoS ONE 8(9):e75604

Results of treatment with cysteamine

doi: 10.1007/s11250-008-9141-6 272 RochaC

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Studies indicate that DCI may intensify TAC by elevating the activities of key antioxidant enzymes such as SOD and CAT, while curbing ROS and MDA, potentially via the forkhead box O (FOXO)/DAF-16 and nuclear factor erythroid 2-related factor 2 (Nrf2)/SKN-1 signaling pathways (59)