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Addressing these challenges could unlock the full potential of copper ionophores in overcoming treatment resistance and improving outcomes in aggressive cancers

Plant J 44:516529 Kombrink E, Schmelzer E (2001) The hypersensitive response and its role in local and systemic disease resistance

In order to avoid class imbalance problems, here we pooled all individual diseases together

References Arranz L, et al

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AP-1 is important for upregulating the transcription of MMP-1, MMP-3 and MMP-9, where excessive MMP expression can cause increased dermal ECM fragmentation (56,58)