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The mutations in the X chromosome are generally associated with intellectual disability syndrome, which is more prevalent in males than in females

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While the regulation of MTHFR activity is closely controlled by SAM at C-terminal regulatory domain, more studies indicated that the human MTHFR enzyme activity is also regulated by multiple phosphorylated sites on a serine-rich N-terminal extension region 20

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G0438 (Initial AWV): Once in a patients lifetime