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This switch is further evidenced in a NMR-based metabolomic profiling study showing increased concentrations of lactate in granulomas from Mtb -H37Rv-infected C57BL/6 mice (85)

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In addition, the treatment of nicotinamide (NAM), a form of vitamin B3, suppressed the activity of sirtuin-1 (SIRT1), a regulator of cellular stress resistance, and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1), a key transcriptional coactivator involved in mitochondrial biogenesis and energy metabolism

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