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10.1136/gutjnl-2011-301404 Gut 40 JarvinenK

The question sits within a broader debate over how much latitude Americans should have to access therapies that have not completed the controlled human trials ordinarily required before a drug reaches the market

Aflatoxin (AFT) Poisoning Aspergillus flavus is a saprophytic filamentous fungus that contaminates both pre-harvest and post-harvest seed crops, producing the carcinogenic secondary metabolite aflatoxin [70], which is a mutagenic, teratogenic, and carcinogenic toxin in animals and humans [71,72]

Beyond the direct translocation of pathogens, the lung microbiota can indirectly modulate CNS disease progression through complex immune and metabolic pathways, frequently in response to or in conjunction with signals from direct translocation

A wrong assumption can lead to a dose that is dramatically higher or lower than intended