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The rise of multidrug-resistant (MDR) bacteria further highlights an urgent need for alternative, next-generation antibacterial treatments

Quickstart Highlights FOXO4-DRI (also known as Proxofim) is a synthetic D-retro-inverso peptide designed to selectively induce apoptosis in senescent cells by disrupting the FOXO4p53 protein interaction [1] [2]

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Finally, as shown in Figure 8D, the group treated with the 40% stretched membrane combined with electrical stimulation displays the thickest granulation tissue on day 14, confirming its substantial effect in promoting structural tissue repair (Wang et al., 2021)

Therefore, chronic inflammation and oxidative stress are not only the core pathological mechanisms of CKD-associated sarcopenia but also promote each other to form a vicious cycle of inflammation-oxidative stress-muscle loss, which exacerbates the deterioration of CKD patients

Neither the researchers or the participants knew who received which treatment until after the study was concluded and the results were analyzed