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In addition, intranasal administration offers the potential advantages of a more rapid onset of action and avoidance of first-pass metabolism [28]

In in vitro cell experiments, it is widely used to verify the relationship between NNMT activity and cellular energy metabolism

doi: 10.1111/j.1530-0277.2008.00620.x [DOI] [PubMed] [Google Scholar] 89.Besheer J, Grondin JJM, Cannady R, Sharko AC, Faccidomo S, Hodge CW

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Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration