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78 HP 160 CAGRILINTIDE Long-Acting Amylin Analog ALIASES Cagrilintide, AM833, long-acting amylin analog CLASS Synthetic amylin analog once-weekly dual amylin/calcitonin agonist FORMULA CHNO (approx) SEQUENCE 37-residue amylin analog with C20-fatty-acid albumin tether HALF-LIFE ~7 days (once-weekly dosing) ROUTES Subcutaneous (Phase 2/3 clinical) MECHANISM OF ACTION Long-acting amylin analog

Herzog, C

Because our structure is of the unmodified SCF FBXO22 complex, some of these interaction surfaces may be altered in the active, neddylated form of the complex

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Although no significant difference in the SERPING1 levels relative to the UFMs was detected in the current study, its inverse association with fasting C-peptide/glucose further suggests its relationship with beta cell function in type 1 diabetes